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patients with symptomatic decline (poor sleep, body composition changes, reduced energy) may be candidates Patients with body composition goals where GH optimization is clinically relevant: body fat accumulation alongside lean mass reduction that has not responded adequately to lifestyle intervention Individuals seeking sleep quality improvement where GH-axis optimization is part of the clinical picture Athletes or active individuals with recovery requirements where GH-mediated protein synthesis is a clinical priority Patients already in a comprehensive longevity program where GH-axis assessment and optimization is part of the protocol The decision to prescribe Ipamorelin or any GH secretagogue begins with a clinical assessment that includes baseline IGF-1 measurement (the primary marker of GH axis activity), review of the patient's symptom profile, and evaluation of contraindications

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Upon activation cues, GSTO1 removes this inhibitory SSG on ASC to enable ASC speck formation and productive inflammasome assembly 68

doi: 10.1016/j.rbmo.2017.03.023

Food Prod Process and Nutr 5 , 48 (2023)