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When the fundamentals are broken, peptides simply highlight the dysfunction

Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes

Second, the observational nature of the study precludes causal inference, and residual confounding is possible

doi: 10.1126/science.271.5247.363

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Apart from hypoglycemic effects, this class of drugs possesses antihypertensive effects, anti-inflammatory effects, antiapoptotic effects, and immunomodulatory effects on the heart, kidneys, and blood vessels independent of the incretin pathway