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While many of these studies are based on animal models, early human trials and anecdotal reports suggest promising results

Studies have implicated TNF- in the pathogenesis of angiogenesis and thrombogenesis, both of which are contributing factors to the development of heart disease [8]

As mentioned previously in Introduction, one of the main limitations of peptide therapeutic drugs is that they are difficult to penetrate the cellular membranes, which is vital to the modulation of PPIs as they only begin working after binding to the target protein intracellular

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Grundy SM, Stone NJ, Bailey AL, et al