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Metabolic improvements (blood sugar, weight loss, body composition) typically become evident at 6-12 weeks

Effect of menopausal status on body composition and abdominal fat distribution

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In the intestine, GLP-1-secreting L cells act as sensors for nutrients, microbes, and inflammatory signals

In this model, Glp1r / mice exhibited reduced weight loss and lowered lung Il6 , Il1b , Ccl2 , and Cxcl2 expression, although survival remained unchanged (77)