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Two important recent examples are the knockouts of the matricellular proteins thrombospondin-2 (TSP2) (35) and SPARC (secreted protein acidic and rich in cysteine) (36)

The Health ABC Study, a three-year longitudinal analysis in 2066 community-dwelling older adults aged 7079, found that those in the highest quintile of protein intake (18.2 % of total energy) lost nearly 40 % less lean mass than those in the lowest quintile ( 1.2 g/kg/day of protein, evenly distributed across meals, alongside resistance training to help preserve lean mass during GLP-1 therapy

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We find that host GSH is required for intracellular survival, and most strikingly, GSH depletion causes intracellular chaining of R

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