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Mendes et al., 2019)

You start low and increase gradually

We employed the GWAS Catalog 22 and Litvar 23 databases to account for previous GWAS

While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful