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Dembiski A, Warzecha Z, Ceranowicz P, et al

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It all started with a "serendipitous discovery in Gila monster venom (yes, really) which eventually led to the first GLP-1 drug approved by the FDA in 2005

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Separations were performed using an Agilent Poroshell 120 HILIC-Z PEEK-lined column with dimensions of 150 mm length, 2.1 mm diameter, and 2.7 m particle size equipped with a guard column of the same phase

Importantly, the study showed consistent results across scales, maintaining product quality while increasing batch sizes