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water-insoluble fillers: talc, calcium carbonate, barium sulfate, or ethylcellulose), mucoadhesive agents (starch, chitosan, gelatin, starch, cellulose derivatives), solubilizers, permeation and absorption enhancers (cyclodextrins, fatty acids, phospholipids, surfactants, bile salts, chelating agents) for better therapeutic efficacy [13,14,32,33,34,35,36]