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Articular cartilage is primarily composed of chondrocytes and an extracellular matrix (ECM), which consists mainly of type II collagen and proteoglycans ( Synovial inflammation and immune dysregulation are also characteristic of OA

This phase II trial demonstrates that enobosarm, a selective AR modulator, shows anti-tumour activity and clinical benefit in women in postmenopause with ER-positive, HER2-negative and AR-positive advanced breast cancer, supporting further investigation of AR activation as a therapeutic strategy

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doi:10.1039/d3fo02791k 250