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mTOR signaling, a downstream target of the insulin/IGF-1 pathway, is a well-known enhancer of the anabolic processes required during the growth phase when its capacity to inhibit autophagy might be beneficial but later in the lifespan, its inhibition promotes the degeneration of aging tissues

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Furthermore, the core component of the Hippo pathway, macrophage stimulating 1 (MST1), is implicated in triggering pyroptosis

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Pharmaceuticals 4(1):187201 Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V et al (2019) L-Citrulline increases nitric oxide and improves control in obese asthmatics