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Cadmium induces hepatotoxicity primarily by disrupting the gut-liver axis, compromising intestinal barrier function and triggering hepatic inflammation

Kikuchi E, Margulis V, Karakiewicz PI, Roscigno M, Mikami S, Lotan Y, et al

Hydrochloric acid and/or sodium hydroxide for pH adjustment if necessary (4.5-7.0)

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The manipulation included disrupting the precursor degradation pathways ( tnaA and sdaA ), eliminating l-glutathione degradation ( ggt and pepT ), and manipulating the intracellular ATP level (disruption of glgB )