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In addition to the NMA, a doseresponse meta-analysis was conducted to evaluate the relationship between supplement dose (mg/day) and weight change at a standardized timepoint of 12 weeks

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Diabetes Care 43:487493

Metabolic improvement following decreases in visceral adipose tissue mass, but not peripheral (subcutaneous) demonstrates a direct relationship between central obesity and metabolic dysregulation

And this study was quite large as far as studies go