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Vitamin B12 is a water-soluble vitamin that is naturally found in animal products such as meat, fish, dairy, and eggs
One milligram kept most of the 2.4 mg weight effect in a diabetes trial, and 0.5 mg has years of use behind it. Small real-world series also suggest that reduced-frequency dosing can hold a plateau
Other targets such as sodium channels can also be affected by high doses of alcohol, and alteration in the numbers of these channels in chronic alcoholics is likely to be responsible for as well as other effects such as cardiac arrhythmia
Research from the STEP trial program shows that 1.0 mg is where the dose-response curve starts to steepen meaningfully
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