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in addition, higher circulating IGF-1 has been linked with increases in MPS, muscle free fatty acid utilization, and improvements insulin sensitivity (Kraemer et al., 2017), which may explain its often linked importance in exercise training adaptations
However, neuroinflammation has also been evidenced by 11 C-(R)-PK11195 PET imaging to be associated with ME/CFS (132), and shown to contribute to the pathophysiology of this disease (133, 134)
Glutathione, a major intracellular non-protein thiol, protects against free radical damage by providing reducing equivalents for several key antioxidant enzymes
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The extent to which this impacted lipogenic products (i.e., fatty acids and triglycerides) and whether this was connected to NRF2 activation was unclear