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Cells were washed with Hanks Balanced Salt Solution (Lonza) buffered with 20 mmol/l HEPES (Sigma) and supplemented with 0.1% BSA (Sigma) (wt/vol.)

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Table 1 A summary compiling key studies and reviews that have described limb-related sensory symptomssuch as tingling, cramping, twisting, coldness, or sensory lossin the context of hyperglycemia or diabetic neuropathy