At the GLP-1 receptor, retatrutide is roughly eight times more potent than tirzepatide, so it engages more receptor per dose
Over the following weeks, well gradually increase your dose until you reach the maximum dose of 2.4 mg, which has been shown to have positive effects on medical conditions such as fatty liver, heart disease, cholesterol levels, high blood pressure, and nonalcoholic steatohepatitis
The goal is tolerability, not effect
If it's been four days or more, skip the missed dose and wait for your next scheduled injection day
10.1038/s41598-021-97967-0 Summary Keywords heart failure, GLP-1, glucagon-like peptide-1, clinical trials, cardiovascular disease, cardiovascular outcome studies, diabetes, obesity Citation Kreiner FF, Hovingh GKK and von Scholten BJ (2022) The potential of glucagon-like peptide-1 receptor agonists in heart failure
Lancet Diabetes Endocrinol 2024;12:545-57.ArticlePubMed 119