As mentioned in the study, administration of exenatide after SCI suppressed C/EBP homologous transcription factor protein (CHOP, a pro-apoptotic transcription factor central to ER stress-mediated apoptosis) while upregulating glucose regulatory protein 78 (GRP78, an ER chaperone with cytoprotective effects) in the injured spinal cord, leading to a significant decrease in tissue damage and a significant increase in oligodendrocyte progenitor cell survival [66]
In addition, irregularities with the thyroid gland or elevations of the hormone prolactin can disrupt the brains ability to communicate with the ovary and result in anovulation
Starting with a lower dose and gradually increasing it as needed allows for optimal benefit and minimizes side effects
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The medication slows gastric emptying, increases feelings of satiety, and reduces hunger signals in the brain, thereby facilitating weight loss when combined with a reduced-calorie diet and increased physical activity
