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The low inhibitory activity was observed in compound 4c with one OMe groups while 4g with two OMe groups in 3,5 positions and one OH on 4 position was revealed higher potency (IC 50 = 4.58 1.23 M)

When investigating the drivers of these trends by drug type, the analyses indicated that increased semaglutide use drove much of the overall growth in GLP-1RA use

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10.7717/peerj.17891 19 FlintA.AndersenG.HockingsP.JohanssonL.MorsingA.SundbyP

Furthermore, the presence of underlying health conditions, such as heart disease or kidney problems, may necessitate dosage adjustments to ensure patient safety and minimize the risk of potential complications

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