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Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

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GLP-1 medication is one part of the plan Semaglutide, tirzepatide, Ozempic, Wegovy, Mounjaro, and Zepbound are names patients often hear before they understand the clinical differences

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Rapid mitochondrial purification for metabolite profiling Mitochondria were purified from HEK-293T, HeLa, or K562 cells expressing 3xHA-OMP25-mCherry (mitochondrial isolation) or 3xMyc-OMP25-mCherry (background control) according to a previously described protocol 40

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