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First, it is able to accumulate specifically in tumor cells, remaining unaffected by MRP while maintaining good cell-membrane permeability

However, some researchers do explore a hybrid model

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IDO1 modulates the sensitivity of epithelial ovarian cancer cells to cisplatin through ROS/p53-dependent apoptosis

It is often used to treat hormonal imbalances, including delayed puberty, infertility, and hypogonadism

3csh: LJ Parker, S Ciccone, LC Italiano, A Primavera, AJ Oakley, CJ Morton, NC Hancock, M Lo Bello & MW Parker (2008) The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterization of allelic variants