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Cold Spring Harbor perspectives in biology , 8 (8), a005926

Singh, I.K ., Espinosa, M.L., Lim, H.W

The best method depends on you, your need, and your comfort level with B12 shots and the subcutaneous method may be the most useful, safe, and convenient way for you

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To be fair, many common supplements like protein powders, collagen, creatine, melatonin, vitamin D, and turmeric are also not FDA-approved

Supplementation is about consistency over intensity