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In the absence of population-specific data, clinical use should be accompanied by vigilant monitoring for class-wide effects (particularly gastrointestinal symptoms) and agent-specific concerns, with dose titration individualized to tolerability
This is based on strong clinical trial evidence they are effective
So they make you eat less, but they functionally change the shape of your body
So, its good to think about how coffee affects you
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(2017) also showed large effects (d = 1.08 and d = 0.94), though improvements were not statistically superior to placebo
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