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Mechanism and gene expression Pickart and colleagues used Broad Institute Connectivity Map data to show GHK-Cu modulates expression of more than 4,000 human genes, with shifts toward patterns associated with younger tissue

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Suppresses M1-ATMs recruitment into epididymal WAT (eWAT) in diet-induced obese mice, attenuating cytokines (e.g., IL-6, tumor necrosis factor- (TNF-)) and chemokines (e.g., macrophage inflammatory protein-1 (MIP-1) and MCP-1)-mediated inflammatory cascades [174, 185]