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In addition to the aforementioned trial investigating the effects of ergothioneine supplementation on cognitive decline (79) , we have recently published our ErgMS study protocol (97) , which aims to investigate the effects of ergothioneine supplementation in middle-aged adults with metabolic syndrome

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Research protocols employ diverse approaches including isolated mitochondria preparations, permeabilized muscle fiber respirometry, stable isotope tracers for metabolic flux analysis, cellular bioenergetics assays (Seahorse), and in vivo metabolic phenotyping in rodent models

MBS can achieve sustained long-term remission of T2D 62 , although remission rates decrease significantly over time

Living with diabetes often means passing through a complex landscape of lifestyle adjustments, medication management, and the ever-present challenge of weight control

Endocrinology 159 , 19641965 (2018)