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Within the SELECT population with BMI 30 kg m 2 or 27 kg m 2 with at least one obesity-related comorbidity, the mean weight loss was 14.9% at week 68, compared with 2.4% with placebo 14

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Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling