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Food and Drug Administration (FDA) has approved several intranasal drugs for acute conditions, including naloxone for opioid overdose and fentanyl for pain management (Madden et al., 2023

Neuroscience 282:1322

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doi: 10.3389/fnins.2015.00194

The animal findings on dopamine system preservation are intriguing given the aging-related decline in dopaminergic tone that contributes to motor and motivational deficits in older adults, but this application should be considered speculative pending human data