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While the clinical phenotype observed in Papillon-Lefvre syndrome (PLS) necessitates careful monitoring of skin and periodontal health during DPP1 inhibition therapy, clinical trials have shown these adverse events occur at low frequencies (1%4%) and are predominantly mild to moderate in severity

The study excluded individuals with type 2 diabetes, despite this population frequently presenting with NAFLD, so it remains uncertain whether these safety outcomes would be applicable to them

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And who's the unsung hero of all these type 2 diabetics who couldn't take metformin

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