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The SUSTAIN 6 cardiovascular outcomes trial, which followed patients for a median of 2.1 years, demonstrated a 26% reduction in the primary composite endpoint of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke compared to placebo

For example, to reflect point about the line \(x = 1\), we translate the point by \([-1, 0]\), reflect it about the \(y\)-axis, and then translate it back by \([1, 0]\)

Source: Xu et al., Nature (2025)

Essentially, high serum B12 can mean that your body is unable to absorb, metabolize, and/or utilize B12 properly, so it remains in your bloodstream

Tirzepatide disrupts this cascade at multiple points