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Key finding: NNMT inhibition reactivated senescent muscle stem cells and improved skeletal muscle regenerative capacity

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Annoni EM, Van Helden D, Guo Y, Levac B, Libbus I, KenKnight BH, et al

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The SNP was shown to have minimal conformational or stereochemical effects on MDA5 itself but is thought to impair the CTD domain within MDA5, weakening the interaction of the protein with dsRNA

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