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Price is often a factor: Because metformin is available as a generic drug, its widely available and much more affordable

Funding Open access funding provided by Centre Hospitalier Universitaire de Lille

One of the most common complaints involves skin irritation

For patients seeking significant, sustained weight loss, GLP-1 efficacy substantially outpaces metformin monotherapy

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For most GLP-1 medications with flexible timing like liraglutide and weekly formulations, you can switch from morning to evening administration, but you should discuss this change with your healthcare provider first