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External Validity The EU-IGFD Registry included an international group of patients treated with mecasermin for growth retardation

Therapeutic peptides as cytolytic agent in breast cancer cells Cytolytic peptides (530 AAs) have amphiphilic and cationic characteristics, allowing them to penetrate cell membranes and kill cells

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In pediatric obesity, dysbiosis is frequently observed and is associated with altered nutrient absorption, increased energy harvest, and heightened inflammatory signaling, thereby reinforcing weight gain and metabolic dysfunction

Treatment with topical and systemic steroids led to recovery [57]

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