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The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

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If yes, retatrutide delivers approximately 6 more percentage points of weight loss at maximum doses while carrying roughly 40-75% higher rates of GI side effects

Their combination produces a synergistic effect documented in the literature