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Although these data suggest that GSH depletion per se, at least for a short period of time, is not sufficient to cause cell injury, a prolonged depletion of mucosal GSH leads to severe degeneration of intestinal mucosal epithelial cells, as shown in BSO-treated mice (Martensson et al, 1990)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Varney J.L., Fowler J.W., Gilbert W.C., Coon C.N

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Additionally, the significant correlations obtained between homocysteine levels and lipid peroxidation parameters suggest that, under our experimental conditions, the observed pro-oxidant effects truly depend on the elevation of circulating homocysteine (Durand et al, 1997a)

Although most of FY2022 saw a return to regular domestic inspection operations, FDA did not resume all foreign inspections until April 2022