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Zafardoust et al., 2020

These chemicals can mimic estrogen in the body, interfere with natural estrogen, or affect how the body makes and breaks down estrogen.9 Everyday estrogen disruptors and where they can be found include:10,11,12 Bisphenol A (BPA) : Found in plastic products, food cans, and dental sealants Phthalates : Used in plastics, personal care products, and food packaging Polychlorinated biphenyls (PCBs) : Industrial chemicals found in old electrical equipment and building materials Polybrominated diphenyl ethers (PBDEs) : Used as flame retardants in furniture, electronics, and textiles Pesticides : Including DDT, atrazine, and organophosphates Parabens : Used as preservatives in cosmetics and personal care products Per- and polyfluoroalkyl substances (PFAS) : Found in non-stick cookware, water-resistant clothing, and food packaging Triclosan : An antibacterial agent used in some soaps and personal care products Heavy metals : Such as lead, mercury, and cadmium Dioxins : Industrial byproducts that can contaminate food and the environment Alkylphenols : Used in detergents, pesticides, and personal care products Symptoms and Health Risks Associated with High Estrogen Common symptoms you might experience if you're young and your estrogen levels are too high, especially if combined with low progesterone, include: Irregular periods Heavy bleeding Bloating and weight gain, especially around the waist and hips Breast tenderness or swelling Mood swings and irritability Headaches Feeling tired all the time Less interest in sex Lumpy or painful breasts Worsening of PMS symptoms Hair loss Trouble sleeping Feeling agitated or blue Some of the health risks associated with excessive estrogens, both natural and synthetic, include:13 Uterine fibroids Thyroid suppression Ovarian cysts Autoimmune issues Infertility Remember, if you're experiencing these signs and symptoms, it's important to talk to a doctor

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In a Phase 3 head-to-head trial, the company compared CagriSemas performance with that of Lillys tirzepatide, which is known to achieve greater weight loss than semaglutide

Patients with family history of these more common thyroid cancers are not automatically excluded from GLP-1 therapy based on this specific contraindication

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