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Most studies report an increased sensitivity to experimental pain and, therefore, a decreased pain threshold in depressed compared to non-depressed subjects especially when emotional aspects of experimental pain are taken into account (Ushinsky et al., 2013)
Use sterile laboratory techniques during handling
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Complicating the matter, administration of ghrelin still leads to cross-desensitization of dopamine-induced Ca 2+ mobilization, and while ghrelin antagonism also reduces this mobilization, it is possible that concurrent cross-sensitization may also occur, which may possibly carry beyond the timeframe of bioavailability of such an antagonist
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