Patients with certain genetic variants may benefit from earlier morning injections if circadian-dependent GLP-1 signaling improves their appetite suppression during waking hours, while others may see equivalent results with evening administration
Authors HW, GW, YF, JL, and MH were employed by Chengdu Huasun Technology Group Inc, LTD
Glucagon receptors are concentrated in the liver and adipose tissue
So, Mounjaro unlike Wegovy has glucose-dependent insulinotropic Polypeptide (GIP) in addition to Glucagon-Like Peptide-1 (GLP-1)
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This study suggested for the first time that GH might regulate the peripheral clock system by affecting the expression of CLOCK and PERIOD genes in humans