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Decreases levels of oxidized (GSSG) Glutathione

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Here, we have used our quantitative thiol-metabolomics method to more accurately measure the levels of derivatised thiol species in a range of artemisinin resistant (Cam3.II R539T , Cam3.II C580Y , PL7, and MRA1240) and sensitive (Cam3.II REV , PL2 and MRA1239) isolates in both 3-6 hpi ring-and 24 hpi trophozoite-stage parasites (Fig 4)

Insulin-sensitive lean subjects (MHL) were identified by a Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), with scores below 1.2, while insulin-resistant obese subjects (MUO) were identified by a HOMA-IR, with scores equal or greater than 2.5 (details are shown in Table 3)