Diabetologia 50 , 806813 (2007)
Preclinical animal models of retatrutide also showed greater reduction in fat mass compared to lean mass, supporting this theory
Athletes competing in drug-tested events should stay informed about potential policy changes and consider the ethical implications of using weight loss medications for competitive advantage
Many people start with semaglutide and switch to tirzepatide if needed, which is a reasonable strategy
Considerable interest exists in identifying effects of these drugs beyond glucose-lowering, possibly resulting in improved macrovascular and microvascular outcomes, including in diabetic kidney disease
All assays relevant to cAMP, LDH, PKA, ATP and Seahorse XFe24 extracellular flux measurements are detailed