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However, Chu found that activation of p53 alone did not significantly downregulate GSH/GSSG ratio, glutathione levels, and GPX4 activity in human cancer cells
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The failure of these antioxidants to seriously modify the toxicity of the herbicide has been attributed mostly to their inability to cross cell membrane barriers and/or to their rapid clearance from cells [3, 4, 6, 7, 10, 11]
doi: 10.1111/j.1365-2125.2012.04278.x
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