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The use of ultrapure dialysate typically was associated with lower C-reactive protein and interleukin 6 levels compared with standard dialysate, thought to be indicative of reduced inflammatory responses

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Secondary endpoints included alterations over the 24-week period in physical assessments, such as body weight, body mass index (BMI), and blood pressure, as well as metabolic parameters, including liver enzymes, renal function, urine albumin excretion ratio (UACR), lipid profile, and uric acid levels

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Clinical interventions targeting NE, such as NE inhibitors like sivelestat, are being explored for their potential to mitigate lung damage and improve outcomes in COVID-19-induced ARDS (128)

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