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They act on the brains dopamine reward system GLP-1s dont just affect digestion

The SURPASS clinical trials involving over 10,000 patients did not identify palpitations as a significant safety signal, with gastrointestinal effects being the most frequently reported adverse reactions

Patients who combine semaglutide with consistent calorie deficit (achieved through reduced portions rather than extreme restriction) see faster results than those relying on medication alone

doi: 10.1007/s11154-019-09511-1 101 ShackleyMMaYTateEWBrownAJHFrostGHanyalogluAC

doi: 10.1038/ijo.2016.52 3 DaviesMJBergenstalRBodeBKushnerRFLewinASkjthTVet al

The amino acid sequence in semaglutide is patented and engineered to maximize effectiveness while maintaining safety profiles established through clinical trials