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Results Metformin alleviated OA pain in MIA-induced mouse model Firstly, an OA model was established by injecting MIA into the knee joints cavity of 6-month-old male C57 WT mice

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FL: Investigation, Writing review & editing

This marks a historical milestone in the development of new pharmacological agents used in the treatment of peptic ulcer disease and other chronic GI-disorders

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Importantly, the BBB functions as the core of the neurovascular unit (NVU), whose integrity depends on the coordinated homeostasis of surrounding neurons, astrocytes, and the basal lamina