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80-INSMSH-E01), plasma lipids were measured through IDEXX bioanalytics and plasma hormones and immune metabolites were measured using the MAP Mouse Metabolic Hormone Expanded Panel (Milliplex, Cat

doi:10.1371/journal.pone.0035683 62

Information provided in this article reflects publicly available guidance as of the publication date and may not reflect the most current regulatory requirements

[5] Calcium is vital for maintaining bone density during weight loss, when bone remodelling may be affected

By enhancing mitochondrial biogenesis and function, and activating AMPK, it ensures that cells are efficient at burning fuel and producing energy

& Stridsberg, M