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Your provider will evaluate your current dose and any side effects before making a transition plan

Naltrexone-bupropion ( Contrave ): Constipation has been reported in over 19% of people taking Contrave

Oral therapy is not always effective, as some persons lack intrinsic factor, an endogenous substance produced by the stomach and necessary for oral B12 absorption

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In a phase 3 clinical trial, a 15-milligram dose of tirzepatide, the highest dose, led to an average weight loss of 22.5% body weight, or about 52 pounds

The key message is that perceived changes in subjective effects don't necessarily indicate reduced therapeutic efficacy