[DOI] [PubMed] [Google Scholar] 41.Rosenstock J, Del Prato S, Franco DR, Vazquez LA, Dai B, Weerakkody GJ, Fernandez LA, Rodriguez A, Bergman B
Note: Inflammation of the pancreas (pancreatitis) has been reported in clinical trials with the GLP-1 agonists
Their mechanism gives them two major downstream effects of interest: improved glycemic control and weight reduction (due to appetite reduction + slower gastric emptying) plus other possible metabolic benefits
Utzschneider et al., 2020), a major question remains: Do SCFAs produced in the gut reach the pancreas in relevant concentrations to influence local receptors
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