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87 These findings clearly indicate that the stimulation of increases in eNOS expression without simultaneously increasing vascular levels of BH 4 may lead to eNOS uncoupling because of the stoichiometric relationship between endothelial BH 4 and NOS activity

Glutathione acts as a powerful antioxidant, detoxifies the liver, and supports immune function, helping to protect cells from oxidative stress

The released Fe 3+ exhausted intracellular GSH via Fenton reaction, boosting ROS production by TCPP-mediated PDT (Figures 2B, C)