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Activation of the NLRP3 inflammasome leads to the cleavage of procaspase-1 into its active form, which in turn processes proinflammatory cytokines such as IL-1 and IL-18 and drives pyroptotic cell death via Gasdermin D activation

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There is also a clear association with primary and secondary Sjogren's syndrome(48)

Alexa Carboni, B., Sabrina Woessner, B., Olnita Martini, M., & Marroquin, N

Immunofluorescence - Anti-Glutathione Peroxidase 4 Antibody (A305439) Immunofluorescence analysis of mouse testis cells using Anti-Glutathione Peroxidase 4 Antibody (A305439) at a dilution of 1:200 (40x lens)