70,71 Additionally, ASOs can form a double-stranded structure complementary to miRNA, leading to its degradation and causing gene upregulation
The trial reported that apitegromab achieved the primary endpoint of statistically significant improvement compared to placebo in motor function from baseline to month 12, as measured by the Hammersmith Functional Motor Scale Expanded (HFMSE) (LSM difference: 1.8 points [p=0.0192] with both doses combined, 1.4 points nonsignificant p=0.1149] with apitegromab 20 mg/kg and 2.2 points [nominal p=0.0121] with apitegromab 10 mg/kg)
Blood-brain barrier protection as a therapeutic strategy for acute ischemic stroke
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