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To further validate the role of the endogenous carnitine shuttle to the observed histone acetylation, we knocked down carnitine O -acetyltransferase (CrAT) and carnitine O -octanoyltransferase (CrOT) (Extended Data Fig

While at the 28th day, a diversity of muscle fiber types still persists resulting in different PAS staining (PAS intensity staining + and +++), at 42nd day this diversity vanished, only residual muscle fibers with low PAS intensity staining were observed (Figure 14a,b)

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Full-length human GLP-1 receptor structure without orthosteric ligands [J]

Koepsell H, Lips K, Volk C