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In the process of development, there will be renal tubular atrophy, glomerular sclerosis, and microvascular sparse, forming a vicious circle and finally, the kidney completely loses its organ function [148]

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Semaglutide, tirzepatide, and retatrutide representing mono-agonist, dual-agonist, and triple-agonist approaches respectively have been studied extensively in clinical trials focused on metabolic function and body composition